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New Analyses Bolster Central Tenets of
Evolution Theory
Pa. Trial Will Ask Whether ‘Alternatives’ Can Pass as
Science
By Rick Weiss and David Brown
Washington Post Staff Writers
Monday, September 26, 2005;
As the Dover trial gets under way, the Hype campaign
starts, and the Darwin blogosphere starts cheering. I hold no
brief for the ID contingent who will probably lose their
incompetent case. But the Darwinists don't deserve to win.
Enough's enough. If half-educated religionists from the Bible
Belt are our only protection against Darwin propaganda, heaven
help us.
Thus an otherwise fascinating article in the Washington
Post appears suspiciously on Day One of the Dover trial
promoting new proofs of Darwin's theory. If it were any other
day than the first day of the new Scopes Trial I would adjourn
for some fascinating study.
If Darwin was right, for example, then scientists should be
able to perform a neat trick. Using a mathematical formula
that emerges from evolutionary theory, they should be able
to predict the number of harmful mutations in chimpanzee DNA
by knowing the number of mutations in a different species'
DNA and the two animals' population sizes.
"That's a very specific prediction," said Eric
Lander, a geneticist at the Broad Institute of MIT and
Harvard in Cambridge, Mass., and a leader in the chimp
project.
[snip]
Their analysis was just the latest of many in such
disparate fields as genetics, biochemistry, geology and
paleontology that in recent years have added new credence to
the central tenet of evolutionary theory: That a smidgeon of
cells 3.5 billion years ago could -- through mechanisms no
more extraordinary than random mutation and natural
selection -- give rise to the astonishing tapestry of
biological diversity that today thrives on Earth.
Yeah, yeah. The central tenet of evolutionary theory?
What's that? More illuminating evidence for descent, no final
conclusion about natural selection. In fact, the language
always gets conveniently scrambled.
The vagueness of language, without any references that I
could find, adjourning after a few paragraphs to the usual
boilerplate about the triumphs of Darwin and claims for
evolution and the evils of ID, leaves the article stranded.
These articles use the 'stun gun' approach for the opening
shot. The reader, even if knowledgeable, is on the defensive
paragraph one, new research, proclamations of the experts,
tough math noone understands, put the reader in 'take your
word for it' mode, too tricky to challenge, fold your cards
one more time. Then cut to the inability of ID to produce
testable predictions. In reality, this is our failed champion
population genetics, beefed up with some interesting genomic
claims, a subject incapable of fully explaining
evolution.
That a mechanism driven by random events should result in
perfectly adapted organisms -- and so many different types
-- seems illogical.
"Even today a good many distinguished minds seem unable
to accept or even to understand that from a source of noise,
natural selection alone and unaided could have drawn all the
music of the biosphere," Jacques Monod, a French
biologist and Nobel Prize winner, wrote in 1970 in the book
"Chance and Necessity."
Natural selection was really hard to accept in
Darwin's day. But it has become easier with the discovery of
genes, DNA and techniques that have made it possible to
watch natural selection happen.
It is illogical! And still really hard to accept, because
it is probably wrong. Why should evolution proceed from a
source of noise? We should on the alert that reductionists are
forcing evolution into their scientific box, and eliminating
something essential. But if they could prove this, that would
be the end of it. But look closely, smoke and mirrors at the
crucial points.
It is now clear from fossil and molecular evidence that
certain patterns of growth in multicellular organisms
appeared about 600 million years ago. Those patterns proved
so useful that versions of the genes governing them are
carried by nearly every species that has arisen since.
I would be the first to acknowledge the complexity of the
Cambrian, and resist misusing it, but Darwinists do
essentially this by ignoring the implications of their own
data. This evidence clearly conceals the problem Darwinists
are having, for it shows a turning point in evolution, which
shouldn't be there, the achievement of a series of basic
structures in a relatively short interval from which a great
diversity in unity appeared. We are not required by the
evidence to take this as confirmation of Darwin's theory. The
fossil record is skewed with a hump, a level of progression
achieved. To simply annex this to Darwinian theory is missing
the obvious. The evidence suggests we are in the presence of
an elusive key we know nothing about yet. To put it plainly,
the record suggests much more reasonably a complex
evolutionary directionality, one that realizes a possible
teleology ( a dangerous term that should be buffered by
empirical statements about directionality) by moving in a step
function progression (not the same as progress,
necessarily) of some sort. In any case we are free to take the
Cambrian interval as evidence of non-random patterning
in the record (such statements avoiding like the plague that
probably false claims for design here, that have driven
Darwinists into their foxhole). At the end of this non-random
pattern interval, we see toolkits come into existence! Come
on. Stop destroying all common sense. I know design theorists
are trying to steal the Darwinists' lunch here. But there's a
source of counterevidence here, and it keeps getting covered
up.
The article thus proceeds to the question of evo-devo,
which probably resolves, or could resolve, many of the
confusions, but which so far has been pressed into service in
Darwin mode, when it should be grounds for liberating theory
from Darwin. The strong suggestion of teleological mechanisms
in DNA processes, these reduced to mutations in regulatory
genes to generalize out of existence the question of
macroevolution, is surely grounds for dissent. Darwinists are
changing their story here. And a complex factor of regulation
doesn't even strike them as discordant with their original
claims. The whole thing is thrown into the Darwin stew. To
suddenly find toolkit genes, the antithesis of pure natural
selection, described in the very language of design, and marry
this to natural selection, using the 'testable predictions' in
isolated cases, and be unable to account for such genes
arising, ought to at least give someone pause to reflect. But
the momentum of the Hype machine is unstoppable. Everyone has
become so confused by the Darwin debate it is impossible to
make any sense of it. Contra Darwin, powerful evidence has
emerged from the genetic revolution for teleological processes
of a natural kind in the realm of DNA structures. That should
make us wonder if something equivalent is not present in the
non-genetic range of full evolution.
Thus, with respect the whole article's claims,
Darwinists are producing more evidence for the claims of microevolution.
This is now sitting ambiguously with the new discoveries of
developmental biology. The missing element, more than
probably a factor of macroevolution (which should be
more than speciation, evolutionary directionality), is simply
unmentioned in the discussion, because it is not supposed to
exist. But the question of the Cambrian, most probably,
powerfully suggests it. But the most important case is that of
the descent of man, where we now know that the Darwin scenario
won't work. First they claimed natural selection explained
(away) macroevolution. Now they claim that natural
selection/mutation in regulatory genes does this job, without
pointing out they have changed their story, and without the
correct proof.
You know what? I think a harmful mutation in Lamarck's
original two level theory produced a degenerate ideological
version of evolution adapted to Darwinian Whigs, attempting to
survive as classical liberals. As S. J. Gould pointed out
(without quite doing him justice) in Structures of
Evolutionary Theory, Lamarck, his nonsense about
adaptation in giraffe's necks apart, had the correct form in
potential for a true theory of evolution, which requires a
two-level approach that avoids the hopelessly confusing
one-level monism of Darwin and his descendants. Moral: mutants
may well prove viable, but real evolution will have to pick up
from the beginning and leapfrog a dead end mess.
Thus population genetics has never been shown to really
explain the phenomenon of evolution, which is well
established, but whose full mechanism defies simple or
complete understanding so far. Note that claims for
microevolution do establish the fact of evolution. The critics
of Darwin in the creationist/Id camp make life easy for Darwin
defenders. All they have to do is show the clear evidence for
microevolution, then change the subject. A true theory must
explore the context of these genetic events, and show the sole
efficacy of natural selection for the total organism, over the
whole stretch of time, and show that speciation, not just in
one, but in all, cases, follows the adaptational scenario.
Microevolution could be simply the bass note in a broader
picture where evolutionary directionality or other factors are
at work.
But decoding chimpanzees' DNA allowed scientists to do
more than just refine their estimates of how similar humans
and chimps are. It let them put the very theory of evolution
to some tough new tests.
It is undoubtedly true, and fascinating that the DNA of chimps
and man are very similar, a powerful argument for the reality
of descent, but not an argument for the mechanism of natural
selection. Man and chimpanzee are brethren in evolution, fine,
a point I find cheering, but they are also dramatically
different species, in their potential and realization, and the
similarity in their DNA gets suspicious. So what? Something is
missing in the whole methodology of genetics if it can't
explicate any of these differences. This isn't a funny
question. The issue of ethical man is so amputated by this
approach that we know almost sight unseen something is goofy
here. They must account for the emergence of an ethical agent,
whose potential to act transcends adaptation, almost by
definition. They simply declare this problem beyond the realm
of science. But then science cannot account for the evolution
of man.
Thus reductionists routinely deny aspects of man that don't
square with the futile effort to produce one-dimensional
continuity. If that's their game, fine, but they should be
quarantined from the public and not be allowed to usurp the
issue of evolution.
In fact, a theory of microevolution is unable to explain
why one or selected lines of simians became hominids, or why
one or selected lines of hominids became homo sapiens,
while all the other branches remained relatively static.
Microevolution was constant through all of this, predictably
so, we have the Seven Daughters of Eve data, but behind all
this a massive change in evolutionary direction occurred that
noone has even documented, let alone explained in a
theory.
Thus bashing ID/creationism for lack of testable
predictions is par for the course, but fails to consider that
most of the claims for Darwinian accounts of the descent of
man make testable predictions that can't really be tested. Did
language evolve by random mutation and natural selection? At
least discipline the argument to acknowledge the evidence is
so far insufficient.
Students of the eonic
effect know the hogwash lurking in such claims, btw. We
know almost certainly now that, as far as the descent of man
is concerned, purely genetic evolutionary theory is
insufficient.
It is an understandable wish to define the problem as one
of science, but even that won't work. What is a science of
evolution? As we look at the sequence chimps/man we find the
transition from evolution to history emerging, and the
adaptational scenario is highly problematical as evolution
closes on the present. We know already that a science of
history gets into contradictions, that evolution and formally
defined history overlap, and that therefore the same doubt
about a theory of evolution for man, at least, is going to
exist. And the evidence is there, almost.
The data of the eonic model predicts that something like an
eonic effect is going to appear in the earlier
evolution/history of man, and sure enough it is there in
the evidence for the Great Explosion. Such statements, we must
be honest where Darwinists are not, are not yet at a critical
threshold in early evolution. But the evidence exists in
recorded history. The point brings home that Darwinian claims
on the descent of man make a host of claims 'testable in the
abstract' but never verified in practice, and probably false.
The whole scenario of microevolution goes on and on, but is
not likely to account for the emergence of man from
chimpanzees. If that is not true, at least provide some proof.
Or have the humility to stand back and say you don't have a
real theory yet.
It is not enough to force evolution in a scientific
standard. To say that something isn't science might mean that
the claim so made means a science of evolution is not possible
for that data. The assumption that there is a full science of
evolution is itself under trial. That doesn't justify going
off the deep end with metaphysical design claims, but it does
remind us that the very gesture of doing science can restrict
the domain of discourse to the point where the phenomenon in
question is shrouded in reductionist confusions, far short of
its full scope.
One might note in closing that the article nicely
references Wallace, for once. Let it be noted that Wallace
actually beat Darwin to the gun, and was the first to publish
a theory of natural selection. The record got rigged by Darwin
and his cronies to highlight Darwin's priority. Apart from
that, Wallace had the honesty later in life to renounce
natural selection in the emergence of man, because he could
see that it won't work. His confusions over spiritual
explanation harmed his case, but his basic point is clear. Man
has a complex potential (which might be embryonically present
in chimps, we don't know) that could never have emerged from
selectionist scenarios. The point is clear from the
simplest attempt to account for the evolution of ethical man.
To sweep this into the category of random mutation/selection
is a sign of either reductionist obsession or complete
stupidity. But to claim that a real theory of evolution exists
as yet is the height of brazen distortions.
All this talk about testable predictions and evidence
confirming natural selection as a macro agent. It isn't there.
It won't work on the descent of man. Students of the eonic
effect are aware of evidence of the one thing Darwinists dread
most, the full scale context behind the low gear
microevolution of genetics. The real evolution of man is
secondarily genetic. Real evolution, at least in the human
case, shows a complexity and range beyond anything Darwinists
could imagine. http://www.history-and-evolution.com/introduction.htm
http://www.history-and-evolution.com/intro1_3.htm
New Analyses
Bolster Central Tenets of Evolution Theory
Pa. Trial Will Ask Whether 'Alternatives'
Can Pass as Science
By Rick Weiss and David Brown
Washington Post Staff Writers
Monday, September 26, 2005; Page A08
When scientists announced last month they had determined
the exact order of all 3 billion bits of genetic code that
go into making a chimpanzee, it was no surprise that the
sequence was more than 96 percent identical to the human
genome. Charles Darwin had deduced more than a century ago
that chimps were among humans' closest cousins.
But decoding chimpanzees' DNA allowed scientists to do
more than just refine their estimates of how similar
humans and chimps are. It let them put the very theory of
evolution to some tough new tests.
If Darwin was right, for example, then scientists should
be able to perform a neat trick. Using a mathematical
formula that emerges from evolutionary theory, they should
be able to predict the number of harmful mutations in
chimpanzee DNA by knowing the number of mutations in a
different species' DNA and the two animals' population
sizes.
"That's a very specific prediction," said Eric
Lander, a geneticist at the Broad Institute of MIT and
Harvard in Cambridge, Mass., and a leader in the chimp
project.
Sure enough, when Lander and his colleagues tallied the
harmful mutations in the chimp genome, the number fit
perfectly into the range that evolutionary theory had
predicted.
Their analysis was just the latest of many in such
disparate fields as genetics, biochemistry, geology and
paleontology that in recent years have added new credence
to the central tenet of evolutionary theory: That a
smidgeon of cells 3.5 billion years ago could -- through
mechanisms no more extraordinary than random mutation and
natural selection -- give rise to the astonishing tapestry
of biological diversity that today thrives on Earth.
Evolution's repeated power to predict the unexpected goes
a long way toward explaining why so many scientists and
others are practically apoplectic over the recent decision
by a Pennsylvania school board to treat evolution as an
unproven hypothesis, on par with "alternative"
explanations such as Intelligent Design (ID), the
proposition that life as we know it could not have arisen
without the helping hand of some mysterious intelligent
force.
Today, in a courtroom in Harrisburg, Pa., a federal judge
will begin to hear a case that asks whether ID or other
alternative explanations deserve to be taught in a biology
class. But the plaintiffs, who are parents opposed to
teaching ID as science, will do more than merely argue
that those alternatives are weaker than the theory of
evolution.
They will make the case -- plain to most scientists but
poorly understood by many others -- that these
alternatives are not scientific theories at all.
"What makes evolution a scientific explanation is
that it makes testable predictions," Lander said.
"You only believe theories when they make non-obvious
predictions that are confirmed by scientific
evidence."
Lander's experiment tested a quirky prediction of
evolutionary theory: that a harmful mutation is unlikely
to persist if it is serious enough to reduce an
individual's odds of leaving descendants by an amount that
is greater than the number one divided by the population
of that species.
The rule proved true not only for mice and chimps, Lander
said. A new and still unpublished analysis of the canine
genome has found that dogs, whose numbers have
historically been greater than those of apes but smaller
than for mice, have an intermediate number of harmful
mutations -- again, just as evolution predicts.
"Evolution is a way of understanding the world
that continues to hold up day after day to scientific
tests," Lander said.
By contrast, said Alan Leshner, chief executive of the
American Association for the Advancement of Science,
Intelligent Design offers nothing in the way of testable
predictions.
"Just because they call it a theory doesn't make it a
scientific theory," Leshner said. "The concept
of an intelligent designer is not a scientifically
testable assertion."
Asked to provide examples of non-obvious, testable
predictions made by the theory of Intelligent Design, John
West, an associate director of the Discovery Institute, a
Seattle-based ID think tank, offered one: In 1998, he
said, an ID theorist, reckoning that an intelligent
designer would not fill animals' genomes with DNA that had
no use, predicted that much of the "junk" DNA in
animals' genomes -- long seen as the detritus of
evolutionary processes -- will someday be found to have a
function.
(In fact, some "junk" DNA has indeed been found
to be functional in recent years, though more than 90
percent of human DNA still appears to be the flotsam of
biological history.) In any case, West said, it is up to
Darwinists to prove ID wrong.
"Chance and necessity don't seem to be good
candidates for explaining the appearance of higher-order
complexity, so the best explanation is an intelligent
cause," West said.
Simple
and Hard
The controversy that has periodically erupted around
evolution can be attributed at least in part to the fact
that it is both simple to understand and hard to believe.
Charles Darwin and Alfred Russel Wallace, working
independently in the early- to mid-1800s, each came up
with the concept of "natural selection." Each
sought to explain the astounding diversity of life he
found in exotic places, Darwin in the Galapagos Islands
and Wallace in Brazil.
Their idea was this:
By some accident of nature whose workings neither man
could explain, an organism may exhibit a variation in
shape, color or body function new to the species. Although
most of these new traits are damaging -- probably lethal
-- a small fraction actually help. They may make it easier
to hide from predators (like a moth's coloration), exploit
a food source (an anteater's long tongue), or make seeds
more durable (the coconut's buoyant husk).
If the trait does help an organism survive, that
individual will be more likely to reproduce. Its offspring
will then inherit the change. They, in turn, will have an
advantage over organisms that are identical except for
that one beneficial change. Over time, the descendants
that inherited what might be termed the "happy
accident" will outnumber the descendants of its less
fit, but initially far more numerous, brethren.
There are two important consequences of this mechanism.
The first is that organisms will tend to adapt to their
environments. If the planet's atmosphere contains lots of
oxygen but very little methane gas, living things are
going to end up tolerating oxygen -- and possibly even
depending on it. But do not expect to see many
methane-breathers.
This appearance of "perfect fit" makes it seem
as if organisms must have been the product of an
intelligent force. But this appearance of perfection is
deceiving. It gives no hint of the numberless evolutionary
dead ends -- lineages that, according to the fossil
record, survived for a while but then died out, probably
because changes in the environment made their once-perfect
designs not so perfect anymore.
The second result of Darwin and Wallace's mechanism is
that over time it will create species diversity. As
additional "happy accidents" alter an organism's
descendants over millions of years, those descendants will
come to look less and less like other organisms with which
they share a common ancestor. Eventually, the descendants
will be able to mate only with each other. They will be
lions and tigers -- each a distinct species, but both
descended from the same ancient cat.
What is hard to understand about this process is that it
is essentially passive. The mechanism is called
"natural selection" because the conditions at
hand -- nature -- determine which accidents are beneficial
and which are not. Organisms do not seek ends.
Giraffes do not decide to grow long necks to browse the
high branches above the competition. But a four-legged
mammal on the savannah once upon a time was endowed with a
longer neck than its brothers and sisters. It ate better.
We call its descendants giraffes.
That a mechanism driven by random events should result in
perfectly adapted organisms -- and so many different types
-- seems illogical.
"Even today a good many distinguished minds seem
unable to accept or even to understand that from a source
of noise, natural selection alone and unaided could have
drawn all the music of the biosphere," Jacques Monod,
a French biologist and Nobel Prize winner, wrote in 1970
in the book "Chance and Necessity."
Natural selection was really hard to accept in
Darwin's day. But it has become easier with the discovery
of genes, DNA and techniques that have made it possible to
watch natural selection happen.
DNA is a stringlike molecule made up of paired beads
called nucleotides. It carries the instructions for making
proteins and RNA, the chief building materials of life.
Individually, these instructions are called genes.
The random changes Darwin knew must be happening are
accidents that happen to DNA and genes. Today, they can be
documented and catalogued in real time, inside cells.
Cells sometimes make errors when they copy their DNA
before dividing. These mutations can disable a gene -- or
change its action. Occasionally cells also duplicate an
entire gene by mistake, providing offspring with two
copies instead of one. Both these events provide raw
material for new genes with new and potentially useful
functions -- and ultimately raw material for new organisms
and species.
Richard E. Lenski, a biologist at Michigan State
University, has been following 12 cultures of the
bacterium Escherichia coli since 1988, comprising
more than 25,000 generations. All 12 cultures were
genetically identical at the start. For years he gave each
the same daily stress: six hours of food (glucose) and 18
hours of starvation. All 12 strains adapted to this by
becoming faster consumers of glucose and developing bigger
cell size than their 1988 "parents."
When Lenski and his colleagues examined each strain's
genes, they found that the strains had not acquired the
same mutations. Instead, there was some variety in the
happy accidents that had allowed each culture to survive.
And when the 12 strains were then subjected to a different
stress -- a new food source -- they did not fare equally
well. In some, the changes from the first round of
adaptation stood in the way of adaptation to the new
conditions. The 12 strains had started to diverge, taking
the first evolutionary steps that might eventually make
them different species -- just as Darwin and Wallace
predicted.
In fact, one of the more exciting developments in biology
in the past 25 years has been how much DNA alone can teach
about the evolutionary history of life on Earth.
For example, genome sequencing projects have shown that
human beings, dogs, frogs and flies (and many, many other
species) share a huge number of genes in common. These
include not only genes for tissues they all share, such as
muscle, which is not such a surprise, but also the genes
that go into basic body-planning (specifying head and
tail, front and back) and appendage-building (making
things that stick out from the body, such as antennae,
fins, legs and arms).
As scientists have identified the totality of DNA -- the
genomes -- of many species, they have unearthed the
molecular equivalent of the fossil record.
It is now clear from fossil and molecular evidence that
certain patterns of growth in multicellular organisms
appeared about 600 million years ago. Those patterns
proved so useful that versions of the genes governing them
are carried by nearly every species that has arisen since.
These several hundred "tool kit genes," in the
words of University of Wisconsin biologist Sean B.
Carroll, are molecular evidence of natural selection's
ability to hold on to very useful functions that arise.
Research on how and when tool kit genes are turned on and
off also has helped explain how evolutionary changes in
DNA gave rise to Earth's vast diversity of species.
Studies indicate that the determination of an organism's
form during embryonic development is largely the result of
a small number of genes that are turned on in varying
combinations and order. Gene regulation is where
the action is.
Consequently, mutations in regulatory portions of a DNA
strand can have effects just as dramatic as those prompted
by mutations in genes themselves. They can, for example,
cancel the development of an appendage -- or add an
appendage where one never existed. This discovery refuted
assertions by Intelligent Design advocates that gene
mutation and natural selection can, at most, explain the
fine-tuning of species.
"The mechanisms that make the small differences
between species are the same ones that make the big
differences between kingdoms," said Carroll, author
of a book, "Endless Forms Most Beautiful," that
describes many of these new insights.
Although the central tenets of evolution have done nothing
but grow stronger with every experimental challenge, the
story is still evolving, Carroll and other scientists
acknowledge. Some details are sure to be refined over
time. The question to be answered in Harrisburg is whether
Intelligent Design has anything scientific to add for now,
or whether it belongs instead in philosophy class.
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